Infusion
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Infusion Nursing Notes by Nufactor provides education, resources and support to promote successful patient therapy within the infusion nursing community.

Lyophilized Powder IVIG: Dilution, Reconstitution, and Pooling

By Derrek Blake, RN, IgCN, and Joe DiStefano, RPh.

Intravenous immune globulin (IVIG) is available as either a liquid or lyophilized (freeze-dried) powder. Initially only powder products were available, requiring reconstitution before administration. Over time, manufacturers changed their manufacturing process to achieve stability of the IgG molecules in a suspended or liquid state. By doing so, the task of reconstitution has been eliminated, making the powder products relatively obsolete. Depending on the brand, IVIG liquid is available in 5% and 10% concentrations. Depending on the brand, IVIG powder is reconstituted to yield a concentration between 3% and 12%. [More]